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Follicular lymphoma

1 OMIM reference -
4 associated genes
14 signs/symptoms

PROTEIN INTERACTIONS: 1

Oculofaciocardiodental syndrome

1 OMIM reference -
1 associated gene
39 signs/symptoms

Follicular lymphoma

Oculofaciocardiodental syndrome

BCL2	(UniProt - OMIM)		BCOR	(UniProt - OMIM)
BCL6	(UniProt - OMIM)
HLA-DRB1	(UniProt - OMIM)
IGH	(UniProt)


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	BCL6	(0.9)	BCOR

Citations in the biomedical literature:

Follicular lymphoma		Oculofaciocardiodental syndrome
	Synonym(s): (no synonyms)		Synonym(s): - Cataract - microphthalmia - radiculomegaly - septal heart defect - OFCD syndrome

	Classification (Orphanet): - Rare hematologic disease - Rare oncologic disease		Classification (Orphanet): - Rare developmental defect during embryogenesis - Rare eye disease - Rare genetic disease - Rare neurologic disease - Rare odontologic disease

	Classification (ICD10): - Neoplasms -		Classification (ICD10): - Congenital malformations, deformations and chromosomal abnormalities -

	Epidemiological data: Class of prevalence: 1-5 / 10 000 Average age onset: adulthood Average age of death: adult Type of inheritance: multigenic/multifactorial		Epidemiological data: Class of prevalence: unknown Average age onset: neonatal/infancy Average age of death: - Type of inheritance: x-linked dominant

	External references: 1 OMIM reference - 1 MeSH reference: D008224		External references: 1 OMIM reference - 2 MeSH references: C537465 / C537735

Follicular lymphoma		Oculofaciocardiodental syndrome
	Very frequent - Fever / chilling - Hematologic / blood / lymphatic cancer - Hyperhidrosis / increased sweating - Lymphadenopathy / polyadenopathies - Weight loss / loss of appetite / break in weight curve / general health alteration Frequent - Asthenia / fatigue / weakness - Mediastinal / hilar adenopathies - Splenomegaly Occasional - Abnormal pleura / hydrothorax / pleuresia / pleural effusion / chylothorax - Anomalies of skin, subcutaneous tissue and mucosae - Bone marrow / medullar infiltration - Lymphedema - Meningitis / meningeal syndrome - Structural anomaly of the peritoneum		Very frequent - Anomalies of teeth and dentition - Anophthalmos / anophthalmia / microphthalmos / microphthalmia - Bifid tip / cleft nose / supernumerary nose - Cardiac septal defect - Cataract / lens opacification - Delayed dentition / eruption of teeth / lack of eruption of teeth - Microcornea - X-linked dominant inheritance Frequent - Abnormal dentition / dental position / implantation / unerupted / dental ankylosis - Anodontia / oligodontia / hypodontia - Cleft palate without cleft lip / submucosal cleft palate / bifid uvula - Flexion deformity of toes (excluding big toe) / hammer toe / camptodactyly of toes - High nasal bridge - High vaulted / narrow palate - Long philtrum - Narrow face - Radioulnar synostosis - Syndactyly of toes Occasional - Anomalies of ear and hearing - Clinodactyly of fifth finger - Coloboma of iris - Cubitus valgus - Feeding disorder / dysphagia / swallowing / sucking disorder / esophageal dyskinesia - Genu valgum - Glaucoma - Hearing loss / hypoacusia / deafness - High arched eyebrows - Intellectual deficit / mental / psychomotor retardation / learning disability - Intestinal / gut / bowel malrotation - Lens dislocation / luxation / subluxation / ectopia lentis - Mitral valve prolapse / incompetence / insufficiency / regurgitation / ring anomaly - Patent ductus arteriosus - Ptosis - Pulmonary valve atresia / stenosis / narrowing - Retinal detachment - Scoliosis - Sensorineural deafness / hearing loss - Solitary median incisor - Thumb hypoplasia / aplasia / absence